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Anticoagulants: Phenobarbital lowers the plasma amounts of dicumarol (identify Earlier made use of: bishydroxycoumarin) and results in a lessen in anticoagulant activity as measured by the prothrombin time. Barbiturates can induce hepatic microsomal enzymes causing increased metabolism and reduced anticoagulant response of oral anticoagulants (e.Si

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